The Americans’ Changing Lives study (ACL) is the longest, ongoing national study to clarify how our neighborhoods, work, and social connections affect our health throughout adulthood. The study began in 1986 with a national face-to-face survey of 3617 adults. Since then, we have interviewed ACL participants in 1989, 1994, 2001, 2011, and 2019. Beginning in 2019, we have also introduced an epigenetic component to the study, collecting and analyzing DNA to understand how neighborhoods and lived experiences affect gene expression. With this 33 years of information, researchers have provided policy makers and the public with important information about the aspects of our social lives that impact our healthy aging.